Avoid or Use Alternate Drug. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Use Caution/Monitor. Consider a starting dose of 25 mg in patients treated with erythromycin. Throw away any unused mixed Revatio oral liquid after 60 days. If you have any questions, ask your doctor or pharmacist.To treat erectile dysfunction-ED, take this drug by mouth as directed by your doctor, usually as needed. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. This drug is available at a higher level co-pay. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Stiripentol is a CYP3A4 inhibitor and inducer. Avoid or Use Alternate Drug. Risk of hypotension. Use Caution/Monitor. dabrafenib will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels, Serious - Use Alternative (1)phenobarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potentially fatal hypotension. efavirenz will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. commonly, these are "non-preferred" brand drugs or specialty Use Caution/Monitor. rifabutin will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potentially fatal hypotension. However, the dose is usually not more than 80 mg 3 times a day. Monitor Closely (1)ribociclib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: additive vasodilation. lopinavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. Sildenafil is a prescription drug. Use Caution/Monitor. Use of Sildenafil (Viagra) in Patients With Cardiovascular Disease Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Monitor Closely (1)sotalol increases effects of sildenafil by additive vasodilation. nitroglycerin translingual, sildenafil. Its major appeal? Adults up to 65 years of age50 milligrams (mg) as a single dose no more than once a day, 1 hour before sexual intercourse. Serious - Use Alternative (1)ivosidenib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Do not store in the bathroom. Erectile Dysfunction. However, your healthcare provider may prescribe it for off-label use in female sexual arousal disorder (FSAD)-a type of sexual dysfunction characterized by low sex drive (libido) in females. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Avoid or Use Alternate Drug. Coadministration of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil) and guanylate cyclase stimulators (eg, riociguat) is contraindicated due to risk of additive hypotension; do not administer within 24 hr of each other. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events; contraindication applies to chronic administration of sildenafil for PAH; for ED, not to exceed 25 mg in 48 hr. Serious - Use Alternative (1)voxelotor will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Patients receiving indinavir with ritonavir should receive not more than 25 mg of sildenafil for treatment of erectile dysfunction in a 48-hour period, and patients receiving other protease inhibitors should use a lower initial sildenafil dose of 25 mg. Information last revised October 2022. Modify Therapy/Monitor Closely. Inititiation of weak CYP2C19 inhibitors may require decreased mavacamten dose. Contraindicated (1)isosorbide mononitrate, sildenafil. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Modify Therapy/Monitor Closely. Multiple myeloma (blood related cancer) or. Contraindicated. Serious - Use Alternative (1)abametapir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sildenafil is also FDA approved under the brand name Viagra for the treatment of erectile dysfunction. Iloperidone is a time-dependent CYP3A inhibitor and may lead to increased plasma levels of drugs predominantly eliminated by CYP3A4. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Viagra online Genuine Viagra makes it possible about Viagra How to Take Sildenafil With Food Before popping that little blue pill, there are a few things you should know. Use Caution/Monitor. If you experience a prolonged or painful erection for 4 hours or more, contact your doctor immediately. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Sildenafil (Oral Route) Proper Use - Mayo Clinic Revatio, Viagra (sildenafil) dosing, indications, interactions, adverse Use Caution/Monitor. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Read and follow these instructions carefully before you start using sildenafil and each time you get a refill of your medicine. Serious - Use Alternative (1)mifepristone will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Alternatively, the medicine may be taken 30 minutes to 4 hours before sexual intercourse. The Food and Drug Administration (FDA) has not approved Viagra (sildenafil) for use in women. For treatment of pulmonary arterial hypertension: For oral dosage forms (suspension or tablets): Adults20 milligrams (mg) 3 times a day. propranolol increases effects of sildenafil by additive vasodilation. Avoid or Use Alternate Drug. Increased systemic exposure of these drugs may occur with clarithromycin; consider reduction of dosage for phosphodiesterase inhibitors. Use Caution/Monitor. Place the tip of the syringe into you or your child's mouth and point it towards the cheek. See coupons Use Caution/Monitor. PDE5 inhibitors have been shown to potentiate the hypotensive effects of organic nitrates. Coadministration with strong CYP3A4 inhibitors and sildenafil (for pulmonary arterial hypertension) is not recommended. When amlodipine and sildenafil were used in combination, each agent independently exerted its own blood pressure lowering effect. Sildenafil should not be used with any other medicine or device that causes erections. Use Caution/Monitor. Monitor Closely (1)nilotinib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)sildenafil, benazepril. carvedilol increases effects of sildenafil by additive vasodilation. . Serious - Use Alternative (1)conivaptan will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Kidney360. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)istradefylline will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potentially fatal hypotension. Manufacturer advises reduce dose to 20 mg twice daily with concurrent use of . Modify Therapy/Monitor Closely. If used concomitantly, monitor for toxicities. maraviroc, sildenafil. apalutamide will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Filter by condition Sildenafil rating summary 8.2/10 average rating 392 ratings from 431 user reviews. Contraindicated. Contraindicated. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by additive vasodilation. The above information is provided for general bisoprolol increases effects of sildenafil by additive vasodilation. Mangoceuticals, Inc. Announces Upcoming Launch of its Sildenafil Based Use Caution/Monitor. Most sotalol increases effects of sildenafil by additive vasodilation. Since high blood pressure in the lungs is a serious condition that can harm both a pregnant woman and her unborn baby, do not stop this medication unless directed by your doctor. Monitor Closely (1)cimetidine will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Serious - Use Alternative (1)pentobarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. Contraindicated (1)nitroglycerin PO, sildenafil. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. erythromycin ethylsuccinate will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)encorafenib, sildenafil. Contraindicated. Patient taking sildenafil for PAH with ritonavir is not recommended. Modify Therapy/Monitor Closely. Monitor Closely (1)grapefruit will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Risk of hypotension. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. It is usually taken as a 20 mg tablet three times a day to help improve exercise capacity and delay disease progression. Mechanism: additive vasodilation. lenacapavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Practice "safe sex" such as using latex condoms. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. labetalol increases effects of sildenafil by additive vasodilation. Risk of hypotension. Contraindicated (1)nitroglycerin transdermal, sildenafil. Sildenafil Oral: Uses, Side Effects, Interactions, Pictures - WebMD This drug is available at a higher level co-pay. Monitor Closely (1)aprepitant will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Severe (eg, cirrhosis): Consider initial dose of 25 mg, Mild or moderate (Child-Pugh A or B): No dose adjustment required, Mild or moderate (CrCl 30-80 mL/min): No dose adjustment required, Severe (CrCl <30 mL/min): Consider initial dose of 25 mg, Any severity, including severe (CrCl <30 mL/min): No dose adjustment required, Maximum dose in pediatric patients not identified, Based on experience in adults, dose may be titrated up to 40 mg TID, if required, based on symptoms and tolerability, elvitegravir/cobicistat/emtricitabine/tenofovir DF, ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC), Body as a whole: Face edema, photosensitivity reaction, shock, asthenia, pain, chills, accidental fall, abdominal pain, allergic reaction, chest pain, accidental injury, Cardiovascular: Angina pectoris, AV block, migraine, syncope, tachycardia, palpitation, hypotension, postural hypotension, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, abnormal electrocardiogram, cardiomyopathy, Digestive: Vomiting, glossitis, colitis, dysphagia, gastritis, gastroenteritis, esophagitis, stomatitis, dry mouth, liver function tests abnormal, rectal hemorrhage, gingivitis, Hemic and lymphatic: Anemia and leukopenia, Metabolic and nutritional: Thirst, edema, gout, unstable diabetes, hyperglycemia, peripheral edema, hyperuricemia, hypoglycemic reaction, hypernatremia, Musculoskeletal: Arthritis, arthrosis, myalgia, tendon rupture, tenosynovitis, bone pain, myasthenia, synovitis, Nervous: Ataxia, hypertonia, neuralgia, neuropathy, paresthesia, tremor, vertigo, depression, insomnia, somnolence, abnormal dreams, reflexes decreased, hypesthesia, Respiratory: Asthma, dyspnea, laryngitis, pharyngitis, sinusitis, bronchitis, sputum increased, cough increased, Skin and appendages: Urticaria, herpes simplex, pruritus, sweating, skin ulcer, contact dermatitis, exfoliative dermatitis, Special senses: Sudden decrease or loss of hearing, mydriasis, conjunctivitis, photophobia, tinnitus, eye pain, ear pain, eye hemorrhage, cataract, dry eyes, Urogenital: Cystitis, nocturia, urinary frequency, breast enlargement, urinary incontinence, abnormal ejaculation, genital edema and anorgasmia, Coadministration with nitrates (either regularly and/or intermittently) and nitric oxide donors, Consistent with the effects of PDE5 inhibition on the nitric oxide/cyclic guanosine monophosphate pathway, PDE5 inhibitors may potentiate the hypotensive effects of nitrates, A suitable time interval following PDE5 dosing for the safe administration of nitrates or nitric oxide donors has not been determined, Potential for cardiac risk with sexual activity in patients with preexisting cardiovascular disease; therefore, treatment for erectile dysfunction generally should not be instituted in men for whom sexual activity is inadvisable because of their underlying cardiovascular status, Evaluate underlying causes of erectile dysfunction or BPH before initiating therapy, In small, prematurely terminated study of patients with PAH secondary to sickle-cell disease, vaso-occlusive crises requiring hospitalization were more commonly reported by patients who received sildenafil than by those randomized to placebo; effectiveness of sildenafil in PAH secondary to sickle-cell anemia has not been established; the clinical relevance to men treated for erectile dysfunction with sildenafil is not known, Epistaxis occurred in 13% of patients with PAH secondary to connective tissue disease (eg, scleroderma); this effect was not seen in idiopathic PAH; incidence was also higher in those receiving concomitant PO vitamin K antagonist therapy (9%) than in those not receiving such therapy (2%), CYP3A substrate (major route); CYP2C9 substrate (minor route), Consistent with its known effects on the nitric oxide/cGMP pathway, sildenafil was shown to potentiate the hypotensive effects of nitrates, Viagra: Modify dose; not to exceed single dose of 25 mg/48 hr, Coadministration increases systemic exposure of sildenafil and risk of adverse effects, Revatio: Modify dose; upward dose titration may be needed if coadministered, Coadministration with moderate-to-strong CYP3A inducers (eg, bosentan) decreases the sildenafil exposure and possibly reduces efficacy, Additive adverse effects may occur if coadministered with other PDE5 inhibitors (eg, avanafil, tadalafil, vardenafil), Coadministration may increase risk of hypotension, Particularly with higher doses used for erectile dysfunction, Take as needed, about 1 hr before sexual activity; however, may be taken anywhere from 30 minutes to 4 hr before sexual activity, The maximum recommended dosing frequency is once daily, Reconstitute bottle contents with water (total volume of 90 mL [60 mL followed by 30 mL]), Refer to prescribing information for detailed instructions, Do not mix with any other medication or additional flavoring agent, Store at controlled room temperature 20-25C (68-77F), Excursions permitted to 15-30C (59-86F), Store <30C (86F) or in a refrigerator between 2-8C (36-46F), Discard unused oral suspension after 60 days. Minor/Significance Unknown. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, sildenafil should be used only when clearly needed. Nirmatrelvir/ritonavir is contraindicated with drugs that are highly dependent on CYP3A for clearance and for which elevated concentrations are associated with serious and/or life-threatening reactions. timolol increases effects of sildenafil by additive vasodilation. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sildenafil in the elderly. Minor/Significance Unknown. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Call your doctor right away if you have blurred vision, confusion, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly, sweating, or unusual tiredness or weakness. Use Caution/Monitor. Use Caution/Monitor. Contraindicated (1)nirmatrelvir/ritonavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sildenafil: Usage, Dosage & Side Effects - Drugs.com Remove the cap by pushing it down and twisting it counter-clockwise. When used for erectile dysfunction, consider reducing initial sildenafil dose of 25 mg in patients also taking a strong CYP3A4 inhibitor and monitor for sildenafil toxicities (eg, dyspepsia, headache, hypotension). Refer to the prescribing information of PDE5 inhibitors for dose recommendations. Patients receiving indinavir with ritonavir should receive not more than 25 mg of sildenafil for treatment of erectile dysfunction in a 48-hour period, and patients receiving other protease inhibitors should use a lower initial sildenafil dose of 25 mg. penbutolol increases effects of sildenafil by additive vasodilation. Patients will use daily tadalafil 5 mg or daily sildenafil 25 mg 4. darunavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. saquinavir increases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Ask your doctor if you have any questions. nitroglycerin topical, sildenafil. primidone will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. STORAGE: Store at room temperature away from light and moisture. encorafenib, sildenafil. Avoid or Use Alternate Drug. The strengths of generic Viagra drugs are 25, 50 and 100 mg. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Monitor Closely (1)erythromycin stearate will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Sildenafil: MedlinePlus Drug Information In these cases, your doctor may want to change the dose, or other precautions may be necessary. Use Caution/Monitor. ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Increased risk of orthostatic hypotension. Use Caution/Monitor. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Monitor Closely (1)acebutolol increases effects of sildenafil by additive vasodilation. Patients receiving indinavir with ritonavir should receive not more than 25 mg of sildenafil for treatment of erectile dysfunction in a 48-hour period, and patients receiving other protease inhibitors should use a lower initial sildenafil dose of 25 mg. isoniazid will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. This document does not contain all possible drug interactions. Manage and view all your plans together even plans in different states. sildenafil increases effects of alfuzosin by pharmacodynamic synergism. Monitor Closely (1)amifostine increases effects of sildenafil by additive vasodilation. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. This drug is available at the lowest co-pay. Use Caution/Monitor. Use of nitroglycerin within a few days of PDE5 inhibitors is contraindicated. lesinurad decreases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. It. If you need emergency medical care for a heart problem, it is important that your doctor knows when you last took sildenafil. Fexinidazole inhibits CYP3A4. Refer to the prescribing information of PDE5 inhibitors for dose recommendations. Sildenafil citrate the active ingredient in brand-name Viagra is one of the most widely used and effective erectile dysfunction medications. Contraindicated. Avoid or Use Alternate Drug. Vardenafil. Monitor Closely (1)verapamil will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. idelalisib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration with strong CYP3A4 inhibitors and sildenafil (for pulmonary arterial hypertension) is not recommended. informational and educational purposes only. Contraindicated. Use Caution/Monitor. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. sildenafil increases effects of nitroglycerin rectal by additive vasodilation. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Adjust dose according to prescribing information if needed. Monitor Closely (1)butabarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)timolol increases effects of sildenafil by additive vasodilation. Sickle-cell anemia (blood disorder)Sildenafil should be used with caution in these patients as problems with prolonged erection of the penis may occur. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. amyl nitrite, sildenafil. Avoid concurrent or sequential use to decrease risk for ototoxicity. fexinidazole will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Alcohol or marijuana (cannabis) can make you more dizzy. Coq10 For Erectile Dysfunction ! Sildenafil 20 Mg Reviews Serious - Use Alternative (1)apalutamide will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. . Sildenafil ist ein PDE-5-Hemmer und unter anderem in Viagra enthalten. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Use Caution/Monitor. Mechanism: additive vasodilation. Use Caution/Monitor. Contraindicated. Use Caution/Monitor. Sildenafil: a review of its use in erectile dysfunction - PubMed If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling. Roman Review 2023: ED, Hair Loss, and More - Medical News Today Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. CMP Pharma, Inc Announces that Liqrev, the First and Only Ready-made Serious - Use Alternative (1)sildenafil increases effects of asenapine by pharmacodynamic synergism. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. per dose 100 mg) as required, to be taken as a single dose; maximum 1 dose per day. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Potentially fatal hypotension. Monitor Closely (1)carbamazepine will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sildenafil Tablets (Erectile Dysfunction) Information - Drugs.com Monitor Closely (1)deferasirox will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)elagolix decreases levels of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Take sildenafil at least 30 minutes, but no more than 4 hours, before sexual activity (1 hour before is the most effective). Additionally, 50 mg of sildenafil was effective in 55% of patients compared to more than 70% of the patients on vardenafil and tadalafil requiring 20 mg for a similar response. Coadministration with duvelisib increases AUC of a sensitive CYP3A4 substrate which may increase the risk of toxicities of these drugs. tobramycin inhaled and sildenafil both increase nephrotoxicity and/or ototoxicity. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy.
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